Start time: 11am ET, 8am PT; TV: ESPN, tennis channel
Tomas Machac vs Sebastian Korda (16)
Korda, pictured, whose game is fluid when on form, easily beat dangerous French surfer Corentin Moutet in the first round. Tomas Machac, the man wearing the shortest shorts in tennis – and a recent Olympic gold medalist in mixed doubles – is another dangerous opponent.
Korda is less vulnerable to Piqué than Moutet and will need to maintain his focus if he wants to continue to host a successful tournament for the American men.
Karolina Pliskova vs Jasmine Paolini (5)
Italy's Paolini has become so dynamic on the WTA Tour this year that it's hard to believe she came out of nowhere. In New York, her deceptive power and intelligent use of angles are back, and Karolina Pliskova of the Czech Republic will likely have a hard time keeping up with her.
Sofia Kenin vs Jessica Pegula (6)
Sofia Kenin defeated 2021 champion Emma Raducanu in three sets with a forehand slice, clever moonballs and crisp groundstrokes that sent a player already lacking rhythm into a tailspin. Kenin is incredibly difficult to beat when she's on form.
But she has a tendency to get into a spin herself when she's already got her opponent in the washing machine. She can't afford that against Pegula, a model of baseline consistency who is once again trying to get past the quarterfinals of a Grand Slam tournament.
Fabian Marozsan vs Daniil Medvedev (5)
Hungarian Marozsan is one of many floaters in the men's singles that no one particularly wants to face – but she has struggled to convert her numerous three-set victories into Grand Slam successes. Medvedev, the 2021 champion, should have had enough in five sets.
Caroline Wozniacki vs Renata Zarazua
Wozniacki ended her career at the US Open last year, making a memorable run to the fourth round.
In her first year back on tour after the birth of her two children, the Dane will now face Mexican Renata Zarazua, who caused a surprise when she eliminated French number 30 Caroline Garcia in the first round.
GO FORWARD
What to watch out for on the fourth day of the US Open: Carlos Alcaraz and Iga Swiatek want to advance